- MODY (Maturity Onset Diabetes of the Young)
- Neonatal Diabetes
- Syndromic Diabetes
Genes and Mutations:
The human body has about 25,000 individual genes. So far, more than 20 have been linked to monogenic diabetes. an error in any one of these genes can cause a child or adult to develop monogenic diabetes, and it can be passed on in the family.
MODY
Maturity Onset Diabetes of the Young (or MODY) is a term used to encompass a group of monogenic forms of diabetes. At times, patients are misdiagnosed as Type 1 / Type 2 Diabetes or Pre-diabetes. Distinguishing MODY from other forms of diabetes can be difficult for patients and clinicians. Some common features associated with MODY are:
- Diabetes develops before the age of 30 years
- Diabetes often runs in families from one generation to the next
- Patient tests negative for all diabetes related antibodies
- Patient uses small amounts of insulin to manage diabetes
- Diabetes may be treated by diet or tablets and does not always need insulin treatment
NEONATAL DIABETES
Diabetes diagnosed in babies is rare. Diabetes diagnosed within the first 6 months of life is called neonatal diabetes mellitus. Neonatal diabetes may be permanent or temporary.
Babies diagnosed with diabetes often have a single gene cause (meaning monogenic). those diagnosed before 6 months of age have an 80% chance of that being linked to a DNA issue.
There are many forms of MODY or genetic causes of diabetes. For more detailed information, please visit: www.monogenicdiabetes.uchicago.edu
